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Single nucleotide polymorphisms in the von Willebrand factor gene in patients with giant-cell arteritis and polymyalgia rheumatica. Giant-cell arteritis (GCA) and polymyalgia rheumatica (PMR) are types of systemic vasculitis with a frequency of about 1-2% in the elderly. GCA and PMR are characterized by a large arterial inflammation and the involvement of the aorta and its branches. Recent genetic association studies have suggested that the occurrence of GCA and PMR is influenced by certain genes. In this study, we explored the hypothesis that common genetic variants within candidate genes influence the predisposition of GCA and PMR. To evaluate this, we genotyped single nucleotide polymorphisms (SNPs) within the genes for Factor V, von Willebrand Factor (VWF), Toll-like receptor (TLR) 3 and CD14 in patients with GCA and PMR and healthy controls. After Bonferroni correction for multiple testing, no significant association was observed. However, haplotype analysis revealed a significant association of the T allele of SNP 1 (rs2274700) and the T allele of SNP 3 (rs1022228) with the occurrence of GCA (p = 0.006 and p = 0.002, respectively). No association was observed with the T allele of SNP 2 (rs1537370) and SNP 4 (rs1059703). These results suggest that SNPs in the VWF gene are associated with GCA.For indispensable reporting on the coronavirus crisis, the election, and more, subscribe to the Mother Jones Daily newsletter. Let me set the scene for you. It’s 2000, and the 2000 election is going on. We’re watching it on TV from the comfort of our living rooms and our living rooms are connected to the internet and we’re on the internet. (Did you know there was a time when the internet was new?) We’re commenting on it via a website called yahoo.com. The political analysts are predicting that Bush will win a landslide. One of the most famous political sites of the day has an idea for Bush supporters to show their support: create a website that will look just like the previous one, except that it’ll be “VoteDaly.com.” Why VoteDaly.com? Well, apparently, the name Daly

 

 

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